Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA . Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B . A recent study showed that, Kat8 (also called Mof or Myst1), a HAT catalyzing H4K16ac, is important for ESC identityHistone methylation is closely linked to transcription. To obtain Fukuda T, Tokunaga A, Sakamoto R, Yoshida N .
Nguyen AT, Zhang Y .
Although left ventricular assist devices are progressively entering clinical practice as a bridge to transplantation and even as an optional therapy, cell replacement therapy presents a plausible alternative to donor organ transplantation. We would like to thank Shinpei Yamaguchi and Gustavo German for critical reading of this manuscript. Accumulating evidence indicates that these barriers converge onto two sequential events: (1) MET; and (2) activation of pluripotency circuitry (The path from a somatic cell to a refined iPSC and the putative epigenetic barriers during the process. Li B, Carey M, Workman JL . Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR .
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Butyrate promotes induced pluripotent stem cell generation. Auberlet JM, Pacaux MP, Anceaux F, Plainchault P, Rosey F . Adult stem cells are found throughout the body unlike embryonic stem cells which are found in the embryo. The mammalian epigenome. However, our understanding of iPSC generation at the molecular level is hindered by the cell heterogeneity arising from each step of reprogramming and the low percentage of cell population that achieves the iPSC fate. Unlike some organs, the heart has a limited ability to regenerate, and dysfunction resulting from significant cardiomyocyte loss under pathophysiological conditions, such as myocardial infarction (MI), can lead to heart failure. tri-, di- or mono-) represent differential transcriptional statuses. This is in part due to the low efficiency of reprogramming and the cell heterogeneity generated during the reprogramming process. The genomic landscape of histone modifications in human T cells. Control of the embryonic stem cell state.
Promotion of reprogramming to ground state pluripotency by signal inhibition. Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z . Global epigenetic changes during somatic cell reprogramming to iPS cells. Embryonic stem cells (ESCs) have the exceptional ability to both self-renew and differentiate into nearly every cell of the human body. Chin MH, Pellegrini M, Plath K, Lowry WE . Lab-specific gene expression signatures in pluripotent stem cells. Krejci J, Uhlirova R, Galiova G, Kozubek S, Smigova J, Bartova E . Loh YH, Zhang W, Chen X, George J, Ng HH .
Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have the capacity to differentiate into any specialized cell type, including cardiomyocytes. Cell fusion-based reprogramming studies demonstrated that ESCs lacking PRC2 component Suz12 or Eed have reduced capacity to reprogram somatic cell nucleiInterestingly, removal of H3K27 methylation is also involved in reprogramming. We apologize to the people whose work cannot be cited due to space limitation. Intermediate epithelial cell that successfully overcomes the second barrier becomes a nascent iPSC, which can self-renew independently of introduced transcription factors. Chromatin in pluripotent embryonic stem cells and differentiation. Therefore, hESC-derived and hiPSC-derived cardiomyocytes (hESC-CMs and hiPSC-CMs, respectively) offer great potential for cardiac regenerative medicine. Stem cell and related work in our lab is supported by NIH (U01DK089565) and HHMI. mC is catalyzed by the DNA methylation can be passively diluted by inhibition of DNMTs through cell cycle progression or actively removed by various potential mechanismsDuring reprogramming, pluripotency genes that are hypermethylated in somatic cells must be demethylated and activated.
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