Natural killer (NK) cells can provide effective immunotherapy for ovarian cancer. These relationships have been reviewed and managed by the University of Minnesota in accordance with its conflicts of interest policies. The main aim of the trial is to assess the safety of the treatment. For example, iPSC can be prodded into becoming beta islet cells to treat diabetes, blood cells to create new blood free of cancer cells for a leukemia patient, or neurons to treat neurological disorders.
2020 Mar 9;20(2):e14.
Induced pluripotent stem cell lines derived from human somatic cells.
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Human pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs) and induced PSCs (iPSCs), are sources for a stable supply of cells for the therapy 5.
After 4 hours incubation with NK cells, the tumor cells were harvested and analyzed.
Therefore, it has been suggested that strategies that could target multiple tumor-associated antigens at once would induce a broader spectrum of anti-tumor immunity and possibly provide more effective and durable protection against cancer.Since the establishment and characterization of human ESC lines, researchers have attempted to evaluate ESC-based whole-cell cancer vaccines due to their ability to deliver multiple oncofetal antigens in one treatment. Mice were treated similar to the protocol with the MA‐148 cells. These results clearly demonstrate that aAPC PB‐NK cells and iPSC‐NK cells are effective in vivo at reducing established ovarian cancer.While these studies represent an important step forward for use of NK cell‐based immunotherapy to treat ovarian cancer, the cell sources currently evaluated were not able to completely eliminate all tumor in the mice, and eventually mice succumbed to the disease.
These studies demonstrate a single dose of any of the three NK cell populations significantly reduced tumor burden. For instance, many early clinical studies using oncofetal antigen-based vaccines focused on single oncofetal antigens with or without immune adjuvants, limiting the level, and duration of the induced anti-tumor immune response due to tumor heterogenicity and fast adaptation of cancer cells. While all three treatment groups demonstrated statistically significant reduction in tumor burden compared to the tumor only group, both the aAPC expanded PB‐NK and iPSC‐NK cells induced a more consistent response in the mice compared to freshly isolated PB‐NK cells.
Kaufman and Dr. Miller consult for Fate Therapeutics. Induced pluripotent stem cells could serve as cancer vaccine Date: February 15, 2018 Source: Stanford Medicine Summary: Induced pluripotent stem cells, or iPS cells, are a …
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A) Phenotype of CD3/CD19 depleted PB-NK… PB-NK cells and iPSC-derived NK cells mediate in vivo killing of ovarian cancer… Analysis of NK cells in blood of mice treated with NK cells. Li et al.
Here, MA148 were again used after tumor had established for 4 days, 3 doses of NK cells were given on day 0, 7, and 14. Given the large expansion potential of either PB‐NK or iPSC‐derived NK cells using aAPCs, generating sufficient cell numbers to carry out multiple doses is very feasible. Flow cytometric analysis of NK cell products.
Currently NK cells are typically isolated from the peripheral blood (PB) of haploidentical donors through CD3 (T cells) and CD19 (B cells) depletion followed by overnight stimulation with interleukin 2 (IL‐2).
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eCollection 2020.
Together with continued improvements in current cancer therapies, iPSC technology provides an additional therapy to add to the antitumor armamentarium, but much more work needs to be done to demonstrate their true …
Tumors were allowed to establish prior to administering NK cells via intraperitoneal injection. Flow plots are representative of at least 3 independent experiments.
Unable to load your delegates due to an error Recently, one oncofetal antigen-based cancer vaccine using autologous induced pluripotent stem cells (iPSCs) demonstrated marked prophylactic and therapeutic potential, suggesting critical roles of oncofetal antigens in inducing anti-tumor immunity.
School of Medicine, University of Pittsburgh, United States
These studies provide the basis to pursue clinical trials using adoptive transfer of iPSC‐derived NK cells to treat refractory ovarian cancer and other solid tumors.Patients with recurrent ovarian cancer face a poor prognosis due to the limited efficacy of standard therapies One of the limitations to these approaches has been the source NK cells.
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