Osafune, K. et al. and JavaScript.Human induced pluripotent stem (iPS) cells resemble human embryonic stem (ES) cells and have the potential to differentiate into all somatic cell types of the body. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. A relevant example is to make isogenic induced pluripotent stem cell lines using gene editing.A highly popular gene editing tool based on a bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) nuclease from A model that aims to offer medical treatment tailored to individual patients.(WGS). Crossref; PubMed; Scopus (1486) Google Scholar), more than 100 reports published in the past three years use disease-specific iPSCs. Murai, K. et al. Although already more than a decade has passed since hESC were first established, there are few reproducible protocols that give functionally transplantable cells and that could be used as standards to compare the differentiation potential of pluripotent lines.However, using available protocols, a side‐by‐side comparison of iPSC with ESC counterparts shows certain variations (Table The degree of differentiation deviance of some iPSC stresses the need of having robust and relatively simple tests to screen the iPSC.
Sanchez-Danes, A. et al. Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.
Orqueda, A. J., Gimenez, C. A. Matsa, E. et al. Miller, J. D. et al. Human iPSC-derived motoneurons harbouring Avorn, J.
Developing predictive assays: the phenotypic screening “rule of 3”. Smith, C. et al. The authors declare no competing financial interests.Reprogramming technique in which a nucleus from a differentiated somatic cell is transplanted into an enucleated oocyte.A type of genetic recombination in which DNA is exchanged between two DNA molecules that share high sequence similarity. Unable to load your delegates due to an error A more efficient method to generate integration-free human iPS cells. Lee, J. K. et al. Jung, C. B. et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Disease characterization using LQTS-specific induced pluripotent stem cells. To obtain Thomson, J. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Kriks, S. et al. Reprogrammed somatic cells from patients are already applied in disease modelling, drug testing and drug discovery, thus enabling researchers to undertake studies for treating diseases 'in a dish', which was previously inconceivable.Get time limited or full article access on ReadCube.Scannell, J. W., Blanckley, A., Boldon, H. & Warrington, B.
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Lu, H. R. et al.
Siedner, S. et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. Although human ES cells have higher genetic stability than human iPS cells, both cell types can be genetically manipulated to generate genotyped matched cell lines, allowing direct comparison of disease-specific genotypes.Both integrating and non-integrating methods are available for reprogramming. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. You can also search for this author in LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Matsa, E. et al. Ohi, Y. et al. The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Physiological characterisation of human iPS-derived dopaminergic neurons.
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Dambrot, C. Passier, R., Atsma, D. & Mummery, C. L. Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models.
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